That can trigger extremely significant effects that go beyond the scope of what the individual runes could normally offer. For instance, Enigma provides +1 to Teleport, which is a solely Sorceress-based skill Enigma makes available to those, for example, Paladins which allows something similar to the devastating D2R Items build to achieve its full potential.
There are Runeword lists on the internet from the original game but one thing to remember is that they are only compatible with items that have gray text; for example, magical items, which are identified by their blue text, don't support Runewords. However, the stats of the item are still important for making the most out of a Runeword So don't get too eager to put runes in the first item that has sockets you find.
The first game is where farming the Countess in Act 1 is a good method of acquiring runes. This can aid in building some of the Runewords at the lower levels that are available, like Stealth (Tal + Eth; boosts to mana recovery, speed of movement, recovery, and other items) also Leaf (Tir + Ral; offers a wide range of useful abilities for Sorcerers).
Through Act 2. you'll get in Act 2 you'll acquire the Diablo 2 Resurrected buy items Cube. When you place certain items inside the Cube will transform them into something completely different. There are numerous recipes however, it's vital to know that even the simplest of gems could be placed inside to upgrade them to a higher level of rarity. Three chips of rubies will become one faulty ruby, whereas three of them will become one, and so on.